DOI: https://doi.org/10.36347/sjmcr.2025.v13i09.047

Pages: 2138-2143

Soft tissue sarcomas (STS) are rare malignant tumors, characterized by abnormal proliferations arising from connective tissue. They represent a heterogeneous group of tumors, both clinically, histologically, and prognostically. Due to their rarity, evolutionary heterogeneity, and histological diversity, soft tissue sarcomas (STS) pose significant challenges in terms of diagnostic pathology, prognostic evaluation, and the development of therapeutic strategies. Our study is etrospective of 65 cases of soft tissue sarcomas managed by the Oncology- Radiotherapy Department of the CHU Mohammed VI in Marrakech, over a five-year period, from January 2019 to December 2023. The aim of our study is to highlight the epidemiological profile, clinical presentation, diagnostic methods, histopathological profile, therapeutic strategy, evolution, and prognosis of these tumors within our healthcare institution. The mean age of our patients was 40.1 years, with a slight male predominance (52.3%). The average consultation delay was 7 months, with the main reason for consultation being the tumor syndrome. Tumors were predominantly located in the lower limb (60%), compared to 29.3% in the upper limb. MRI was the reference examination performed in 80% of our patients, while histopathological examination was conducted in all patients. Histological evidence was obtained for all patients : 63.1% through surgical biopsy and 36.9% through percutaneous biopsy. Synovial sarcoma (40%) was the predominant histological type, followed by liposarcoma (20%) and leiomyosarcoma (10.8%). The initial treatment was surgical, with conservative surgery performed in 86.1% of patients and radical surgery in 13.9%. Surgical margins were R0 in 58.6% of cases, R1 in 34.5%, and R2 in 6.9%. Adjuvant radiotherapy was associated with surgery in 72.7% of patients, while chemotherapy was administered to 55.6% of patients. Follow-up allowed the detection of 18 cases of local recurrence (40%) and 8 cases of pulmonary met