DOI: https://doi.org/10.36347/sjmcr.2025.v13i10.041

Pages: 2364-2365

Background: Duodenal adenocarcinoma is a rare and aggressive malignancy, accounting for less than 1% of all gastrointestinal cancers. Early detection is crucial, yet diagnosis is often delayed due to nonspecific presentations in primary care settings. Case Presentation: A 44-year-old previously healthy man presented to a primary care clinic with a 10-day history of flu-like symptoms, followed by abdominal pain, swelling, jaundice, and lower limb edema. Investigations revealed abnormal liver function tests, and imaging showed multiple hepatic lesions suspicious for metastasis. Liver biopsy and PET scan confirmed primary duodenal adenocarcinoma. Given his poor performance status, curative surgery and chemotherapy were deemed unsuitable, and palliative care was initiated. The patient passed away 17 days after initial presentation. Conclusion: This case highlights the diagnostic challenges of duodenal adenocarcinoma in primary care and underscores the pivotal role of family physicians in recognizing atypical or vague symptoms of malignancy. Their position within the community allows for early detection, education, and close coordination within multidisciplinary cancer care teams.