DOI: https://doi.org/10.36347/sjmcr.2025.v13i10.071

Pages: 2487-2490

Background: Myoepitheliomas of soft tissues are extremely rare neoplasms of uncertain histogenesis, accounting for less than 1% of all soft-tissue tumors. They belong to the “mixed tumor/parachordoma” family in the WHO classification. Their occurrence in the foot is exceptional, with fewer than ten cases reported in the literature. Case Presentation: We report the case of a 54-year-old male presenting with a progressively enlarging mass located in the first interdigital space of the right foot. Magnetic resonance imaging (MRI) revealed a well-circumscribed, lobulated soft-tissue lesion measuring 95 × 55 × 35 mm, displaying hypointense signal on T1 and hyperintense signal on T2 with heterogeneous enhancement after gadolinium administration. Histopathological examination of a biopsy specimen demonstrated an epithelioid proliferation composed of polygonal and plasmacytoid cells arranged in nests and lobules, separated by fibrous septa. Immunohistochemistry showed positivity for AE1/AE3, EMA, PS100, and INI-1, with negativity for CD34, Desmin, AML, and ACE, and a Ki-67 index of 5%. Complete surgical excision was performed with satisfactory functional outcome and no recurrence after six months of follow-up. Conclusion: Myoepithelioma of the foot is a rare benign tumor. The diagnosis relies on histopathological and immunohistochemical analysis. Surgical excision remains the treatment of choice, with regular follow-up recommended due to the risk of local recurrence