DOI: https://doi.org/10.36347/sjmcr.2025.v13i10.084

Pages: 2536-2539

Ewing sarcoma is a rare, aggressive primary bone tumor, most commonly affecting children and young adults. Its occurrence in the proximal humerus with extension to the glenohumeral joint and adjacent neurovascular structures is exceptionally uncommon and presents significant diagnostic and therapeutic challenges. We report the case of a 27-year-old male presenting with progressive shoulder pain, swelling, and limited range of motion. Imaging studies, including plain radiograph, MRI and CT, revealed a lytic lesion of the humeral head with intra-articular extension and close proximity to the axillary neurovascular bundle. Histopathological analysis confirmed the diagnosis of Ewing sarcoma. The patient underwent neoadjuvant chemotherapy followed by surgical resection, with careful preservation of neurovascular structures. This case highlights the importance of early recognition and multidisciplinary management in proximal humeral Ewing sarcomas involving the joint and neurovascular bundle. Optimal outcomes rely on prompt diagnosis, precise surgical planning, and a combination of chemotherapy and, when indicated, radiotherapy to achieve oncologic control while preserving shoulder function.