DOI: https://doi.org/10.36347/sjams.2025.v13i10.013

Pages: 1764-1765

We received a specimen of right hemicolectomy in a case of 35 years male, presented with persistent abdominal pain for last 6 months. Patient was admitted with sevre abdominal pain and frequent episodes of haematochezia for last 15 days. On gross examination of right hemicolectomy specimen, no obvious growth was found, only thickening of caecal wall was noted. Microscopical features showed atypical discohesive cells involving muscle fibers, serosal fat and subserosal lymph node. These discohesive cells having pleomorphic nuclei, nuclear grooving, prominent nucleoli surrounded by foamy to eosinophilic cytoplasm. Coagulative tumor necrosis was also present in the wall of the colon. Morphologically our initial diagnosis was non-Hodgkin’s lymphoma or poorly differentiated carcinoma or neuroendocrine tumor. Diagnosis of Histiocytic Sarcoma was confirmed by the immunohistochemistry study using CK, Chromogranin, Synaptophysin, CD20, CD3, S100, CD 45 and CD 68. In our case the tumor cells were diffusely positive for CD45 and CD 68. Tumor cells were CK, Chromogranin, Synaptophysin, CD20, CD3, and S100 negative.