DOI: 10.36347/sasjs.2023.v09i12.013

Pages: 1012-1016

Background: Lower urinary tract symptoms (LUTS) are common in aging men and are frequently associated with benign prostatic hyperplasia (BPH). Serum prostate-specific antigen (PSA) is widely used as a marker for prostate pathology and several studies suggest a correlation between PSA levels and prostate volume. This study aimed to evaluate the relationship between serum PSA and prostate volume in Bangladeshi men presenting with LUTS. Methods: This cross-sectional analytical study was conducted in the Department of Urology, Bangladesh Medical University, Dhaka, from July 2022 to June 2023. A total of 80 male patients aged ≥45 years with LUTS were consecutively enrolled. Results: The mean age was 62.1 ± 8.9 years. The mean BMI was 26.1 ± 3.0 kg/m², with 56.3% hypertensive and 33.8% diabetic. Median duration of LUTS was 4 months (IQR: 2–9) and mean IPSS was 17.8 ± 6.0. Mean serum PSA was 5.06 ± 7.95 ng/mL (median 3.46) and mean prostate volume was 38.05 ± 26.65 mL (median 35.3). Higher PSA levels corresponded with larger prostate volumes. Correlation analysis showed a strong positive association between PSA and prostate volume (Pearson r = 0.828, 95% CI: 0.74–0.89; Spearman ρ = 0.808, 95% CI: 0.71–0.87; both p < 0.001). Conclusion: Serum PSA demonstrates a strong positive correlation with prostate volume in Bangladeshi men with LUTS and can serve as a reliable, non-invasive indicator of prostatic enlargement.