DOI: https://doi.org/10.36347/sjmcr.2025.v13i11.055

Pages: 2886-2889

Introduction: Inverted papilloma (IP) is a benign neoplasm of the paranasal sinuses that, despite its non-malignant nature, exhibits aggressive local behavior with the potential for recurrence and, in rare cases, intracranial invasion. Originating in the Schneiderian mucosa, this tumor represents between 0.5 and 4% of primary nasal tumors, primarily affecting men in their fifth and sixth decades of life. The pathogenesis of IP has been linked to multiple factors, including viral factors such as the human papillomavirus (HPV); however, its exact etiology remains under investigation. [1] Clinical case: We present the case of a 56-year-old male patient with symptoms of nasal airway obstruction and headache, who was diagnosed with an inverted papilloma after rhinoendoscopy and computed tomography revealed invasion of the skull base. A complex surgical intervention was performed, including craniotomy and tumor excision, with a histopathological report confirming the diagnosis. Three months postoperatively, the patient showed no surgical scarring or recurrence. After two years of follow-up, no recurrence was observed, and the patient received adjuvant oncological treatment. Discussion: Although inverted papilloma is benign, its potential for malignant transformation and characteristics of local invasion are concerning. The incidence is low, and intracranial invasion is rare, with craniofacial resection being the most effective technique in these cases. It is crucial to avoid conservative treatments, given the risk of recurrence. Long-term follow-up is recommended due to the possibility of late recurrences. [3] Conclusion: Inverted papilloma with cranial invasion, although infrequent, require careful surgical management and long-term follow-up to ensure a favorable prognosis. Endoscopic resection is effective in cases without intracranial extension, while adjuvant radiotherapy may be beneficial in incomplete resections. [5]