DOI: https://doi.org/10.36347/sjams.2025.v13i12.002

Pages: 1975-1977

Colorectal cancer (CRC) remains a major global health burden, with standard treatments often limited by toxicity, resistance, and poor targeting. Peptide-based therapies offer a compelling alternative due to their high specificity, modifiability, and favorable pharmacokinetic profiles. This editorial discusses recent advances in peptide applications for CRC, including diagnostic peptides, tumor-targeting peptides, cell-penetrating peptides (CPPs), and peptide vaccines. Key preclinical and early clinical studies are highlighted, mechanisms of action are elucidated, and challenges such as stability, delivery, and immunogenicity are examined. Finally, future directions to accelerate translation of peptide-based CRC therapies, emphasizing rational design, bioinformatics, and personalized medicine are proposed.