DOI: https://doi.org/10.36347/sasjs.2025.v11i12.010

Pages: 1117-1121

Objective: To evaluate the management and prognosis of locally advanced breast cancer in the Surgery Department A of the Point G University Hospital. Patients and Methods: This was a retrospective, single-center study of patients treated for locally advanced breast cancer in the Surgery A Department of the Point G University Hospital over a 5-year period from January 2015 to December 2020. Results: The study included 81 patients, representing 66.6% of breast cancer cases operated on in the department during the study period. The average age was 46.33 years, with extremes of 20 and 79 years. In 49.4% of cases, the patients had no formal education. In 48% of cases, the time between the onset of symptoms and consultation was more than one year. In 32.1% of cases, the breast was inflammatory. The right breast and the upper outer quadrant were the most affected, accounting for 48% and 34.6% of cases, respectively. Breast fine needle aspiration was performed in 32.1% of patients. Non-specific invasive carcinoma was the most common histological type, accounting for 96.2%, with SBR Grade II being the most prevalent, accounting for 92.1% of cases. Immunohistochemistry was performed in 18 patients (22.2%), with triple-negative tumors being the most common (55.5%). The tumor was stage IIIB in 79% of patients. The combination of surgery and chemotherapy was the most commonly used treatment, accounting for 76.5% of cases. Neoadjuvant chemotherapy, hormone therapy with tamoxifen, and radiotherapy were performed in 90.1%, 14.8%, and 6% of patients, respectively. Total mastectomy combined with axillary lymph node dissection (ALND) was performed in all patients. Postoperative complications included lymphedema in 8.6% of cases and tumor recurrence in 22.2% of cases. Tumor recurrence was observed in 88.9% of patients who did not undergo radiotherapy. In 37.5% of cases, patients who did not receive neoadjuvant chemotherapy experienced recurrence. The survival rate was 79% at 1 year; 72