DOI: https://doi.org/10.36347/sjmcr.2025.v13i12.014

Pages: 2954-2956

Background: Quetiapine, an atypical antipsychotic frequently prescribed for psychotic and mood disorders, is generally well tolerated. Dermatological adverse reactions are rare but clinically significant, warranting careful attention. Case presentation: We report the case of a 34-year-old female treated for a major depressive episode with anxiety comorbidity who was receiving paroxetine 20 mg daily. Quetiapine 25 mg was added at bedtime to manage persistent insomnia. Two days after initiation, she developed an erythematous, intensely pruritic, maculopapular rash affecting the upper chest, neck, back, and left cheek. There was no mucosal involvement, fever, or swelling. Laboratory findings were within normal limits. Quetiapine was promptly discontinued, and the patient was treated with an oral antihistamine, leading to complete resolution within two weeks. Conclusion: This case strikingly illustrates a probable quetiapine-induced cutaneous hypersensitivity reaction occurring even at a remarkably low dose. Clinicians should remain vigilant for dermatological side effects, promptly recognize them, and report such cases to enhance pharmacovigilance data.