DOI: https://doi.org/10.36347/sjmcr.2025.v13i12.017

Pages: 2962-2963

Priapism is a urological emergency defined by a prolonged, painful penile erection unrelated to sexual stimulation. It is a recognized side effect of some antipsychotic medications, usually due to their alpha-1 adrenergic receptor antagonism. We present the case of a 51-year-old male, with a 25-year history of chronic schizophrenia, who developed ischemic priapism just 48 hours after the reintroduction of oral haloperidol at a therapeutic dose of 9 mg/day (30 drops three times daily). This report highlights a rare but critical adverse drug reaction in a patient with long-term psychiatric illness, underscoring the necessity of clinical vigilance, even in individuals with extensive exposure to antipsychotics.