DOI: https://doi.org/10.36347/sjmcr.2025.v13i12.025

Pages: 2992-2993

Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction, rarely associated with central nervous system (CNS) demyelination. We present a rare pediatric case of an 8-year-old girl with known MG and positive family history, who presented with limb hypotonia more pronounced in the lower extremities. Brain MRI demonstrated multifocal demyelinated plaques in the corpus callosum and bilateral centrum semiovale. These findings are not explained by MG and suggest a coexisting CNS demyelinating process. This case highlights the importance of considering “cross-syndrome” overlap in pediatric MG patients with atypical neurological symptoms.