DOI: https://doi.org/10.36347/sasjm.2025.v11i12.016

Pages: 1235-1238

Background: Anterior uveitis is a common inflammatory ocular condition, most often idiopathic or associated with autoimmune or infectious diseases. Its association with solid tumors is rare and may represent a paraneoplastic phenomenon. Case Presentation: We report the case of a 51-year-old man with no significant medical history who presented with recurrent episodes of unilateral anterior uveitis. Despite appropriate topical treatment, the uveitis relapsed several times, prompting an extensive etiological work-up. Clinical examination incidentally revealed a painless soft-tissue mass in the thigh. Imaging studies showed a large deep-seated tumor, and histological analysis confirmed the diagnosis of liposarcoma. The patient underwent surgical resection followed by adjuvant radiotherapy. After oncological treatment, no further episodes of uveitis were observed. Conclusions: This case highlights the importance of considering an underlying neoplastic process in patients with recurrent or unexplained uveitis. A thorough systemic examination may reveal occult malignancies, and appropriate treatment of the underlying tumor can lead to resolution of ocular inflammation.