DOI: https://doi.org/10.36347/sasjm.2026.v12i01.010

Pages: 61-63

Marchiafava-Bignami disease is a rare neurological condition characterised by necrosis and demyelination of the corpus callosum, usually associated with chronic alcoholism and/or malnutrition. The clinical manifestations of Marchiafava-Bignami disease are diverse and often non-specific. The diagnosis of Marchiafava-Bignami disease is based on magnetic resonance imaging results, which reveal significant and symmetrical damage to the corpus callosum. We report the case of a 63-year-old man with chronic alcoholism who had been experiencing symptoms of confusion for several days. Brain CT imaging revealed diffuse and complete damage to the corpus callosum, characteristic of a severe form of Marchiafava- Bignami disease.