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SAS Journal of Medicine | Volume-12 | Issue-02
Daratumumab in the Treatment of Relapsed/Refractory Multiple Myeloma: Real-World Experience from the Clinical Hematology Department of Avicenne Military Hospital, Marrakech
S. Othniel J. KABORE, H. Lehlali, W.S. Ouedraogo, M. Hamidine, M.A. Aznag, S. Achouch, A. Raissi
Published: Feb. 19, 2026 | 17 11
DOI: https://doi.org/10.36347/sasjm.2026.v12i02.010
Pages: 125-127
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Abstract
Multiple myeloma (MM) is a malignant hematologic disorder characterized by clonal proliferation of tumor plasma cells. Treatment of MM has evolved over recent decades, improving progression-free survival (PFS) and overall survival (OS). Daratumumab has demonstrated superior efficacy when combined with other agents, with an acceptable safety profile. This retrospective study evaluates the efficacy and safety of daratumumab in 8 patients with relapsed/refractory MM. Results showed a treatment response in 75% of patients, with a 12-month progression-free survival of 75% and a 12-month overall survival of 87.5%. Daratumumab is an effective and well-tolerated treatment for patients with relapsed/refractory MM.