DOI: https://doi.org/10.36347/sasjm.2026.v12i03.003

Pages: 176-180

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that mainly affects males and manifests itself in episodes of hemolysis, often triggered by certain medications, foods, or infections. It is one of the most common genetic disorders in the world. It affects more than 400 million people, mainly in Africa, Asia, the Middle East, and the Mediterranean Basin. The frequency of G6PD deficiency is relatively high in some sub-Saharan African countries. Among the 200 variants of G6PD described worldwide, the G6PD A- variant (G202A/A376G) predominates in sub-Saharan Africa, where it affects 15 to 20% of the African population. G6PD deficiency can cause massive intravascular hemolysis triggered by oxidizing agents, and this hemolysis can complicate acute renal failure (ARF), which is usually reversible but may even require extrarenal purification. We report the case of a 16-year-old patient who had two successive episodes of ARF in the context of anemia, which investigations revealed to be due to G6PD deficiency. The objective of this study was to observe a rare case of two episodes of acute renal failure in the same patient caused by G6PD deficiency.