DOI: https://doi.org/10.36347/sjmcr.2026.v14i03.057

Pages: 560-562

Background: Secondary syphilis is a systemic manifestation of Treponema pallidum infection characterized by highly polymorphic mucocutaneous lesions. Palmoplantar involvement is a characteristic but often overlooked sign. Syphilis and HIV coinfection is increasingly reported and represents a major public health concern. Case presentation: A 47-year-old man presented with a generalized non-pruritic maculopapular eruption involving the trunk, extremities, palms, and soles. He reported a prior painless genital ulcer and high-risk sexual behaviour. Serological tests confirmed secondary syphilis, and HIV screening revealed previously undiagnosed infection. Treatment with intramuscular benzathine penicillin G led to rapid clinical resolution of cutaneous lesions. Conclusion: This case highlights the diagnostic value of palmoplantar involvement in secondary syphilis and underscores the importance of systematic HIV screening. Dermatologists play a pivotal role in the early detection of sexually transmitted infections.