DOI: https://doi.org/10.36347/sasjs.2026.v12i04.004

Pages: 271-274

Fungal endocarditis is a rare but life-threatening condition, particularly in patients with prosthetic valves or recent cardiac surgery, and its optimal management remains challenging. We report the case of a 22-year-old Moroccan woman with a history of mitral valve repair who presented with acute heart failure and infective endocarditis requiring urgent double valve replacement. The postoperative course was complicated by persistent fever, negative bacterial cultures, and multiple embolic events. Fungal blood cultures later identified Candida glabrata. Intravenous voriconazole therapy resulted in rapid clinical improvement and resolution of echocardiographic lesions without the need for repeat surgery. Early suspicion of fungal infection is crucial in patients with persistent postoperative infection and negative bacterial cultures. Although combined medical and surgical management is generally recommended, this case illustrates that prompt targeted antifungal therapy may achieve favorable outcomes in carefully selected patients when early reoperation carries substantial risk.