DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.004

Pages: 608-610

Testicular germ cell tumors [GCTs] are the most common malignancies in young adult males. Recurrence after orchiectomy and chemotherapy, particularly in non-seminomatous tumors or mixed GCTs, represents a significant clinical challenge. We report the case of a 72-year-old patient who underwent left orchiectomy in 2024 for a left testicular mass. Initial histopathology confirmed a pure seminoma. The patient received first-line BEP chemotherapy with good response, followed by surveillance. One year later, he presented with retroperitoneal lymph node recurrence, for which second-line TIP chemotherapy was administered, resulting in a significant tumor response and normalization of tumor markers. Persistent retroperitoneal masses were subsequently identified on imaging, suggestive of mature teratoma. A multidisciplinary team recommended surgical excision of residual masses. This case highlights the importance of long-term follow-up, the role of tumor markers and imaging in monitoring recurrence, and the surgical management of residual disease in testicular GCTs.