DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.006

Pages: 615-618

Clear cell renal cell carcinoma (CCRCC) is the most common type of kidney cancer and often progresses asymptomatically, with up to one-third of patients presenting with metastases at diagnosis. We report the case of a 47-year-old man who presented with a progressively enlarging frontal mass, a first generalized tonic-clonic seizure, and a first-degree atrioventricular block. Brain imaging revealed a hypervascular osteolytic frontal lesion suggestive of a bone metastasis. Further thoraco-abdomino-pelvic CT scan showed a 12 cm right renal mass (T3a) with frontal and humeral bone metastases. Laboratory findings included normocytic anemia and a moderate inflammatory syndrome. Percutaneous renal biopsy confirmed grade 3 CCRCC (Fuhrman). The patient received multidisciplinary care including antiepileptic therapy with levetiracetam, systemic therapy with the tyrosine kinase inhibitor sunitinib, and palliative radiotherapy for metastatic bone pain. This case highlights the rare presentation of CCRCC as a frontal bone metastasis revealed by a seizure, emphasizing the need for prompt multidisciplinary evaluation in atypical presentations.