DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.010

Pages: 631-635

Introduction: Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare clinicopathological entity characterized by the association of acute tubulointerstitial nephritis and uveitis in the absence of other systemic diseases. Because renal and ocular manifestations may occur at different times and symptoms are often non specific, the diagnosis may be delayed or overlooked. The aim of this study was to describe the clinical, biological, histological, and therapeutic characteristics of patients diagnosed with TINU syndrome in a tertiary care center. Materials and Methods: We conducted a retrospective monocentric study in the Department of Nephrology, Dialysis and Renal Transplantation at Ibn Sina University Hospital in Rabat, Morocco. Medical records of patients diagnosed with TINU syndrome were reviewed. The diagnosis of TINU syndrome was established based on the association of acute tubulointerstitial nephritis and uveitis after exclusion of other systemic diseases. Demographic, clinical, biological, ophthalmological, histological, therapeutic, and outcome data were collected. Results: Eight patients with TINU syndrome were included, with a mean age of 27.8 ± 8.1 years and a female predominance. Ocular involvement preceded renal manifestations in five patients, with a median delay of 2 months, and was concomitant in the remaining cases. All patients presented with acute kidney injury, with a mean serum creatinine level of 808.2 ± 528.4 µmol/L. All patients received oral corticosteroid therapy combined with adjunctive measures. Complete renal recovery was achieved in six patients (75%), while one patient progressed to chronic kidney disease and one to end-stage renal disease. No renal relapse was observed. Uveitis relapse occurred in three patients (37.5%), with a mean delay of approximately 6 months. Discussion: The pathogenesis of TINU syndrome remains incompletely understood but is thought to involve immune-mediated mechanisms targeting shared antigens bet