DOI: https://doi.org/10.36347/sajp.2026.v15i04.001

Pages: 57-71

Current study aims to summarise the different health-beneficial potential activity of non-platinum metal-based organic compounds. Literature analysis shows that the organic complexes of Ag, Au, Co, Cu, Fe, Mn, Mo, Ni, Zn, Ce, Ga, Gd, Ir, Os, Pd, Re, Rh, Ru, Ti, V, have been investigated to possess different pharmacological action. The more pronounced effects of metal complexes are combinations of anticancer and the following different activities: 1) anti-Alzheimer: Co, Cu, Ni, Pd, Ru, V; 2) antioxidant: Co, Cu, Fe, Ni, Zn, Mn, Ce, Nd, Ga, La; 3) antimicrobial: Ag, Au, Cr, Co, Cu, Fe, Mn, Ni, Zn, Ga, Ir, La, Pd, Ru; 4) antimalarial: Au, Co, Cu, Fe, Zn, Ga, Os, Pd, Rh, Ru; 5) anti-Mycobacterium tuberculosis: Cu, Fe, Os, Ru; 6) antifungal: Co, Cu, Ni, Ru, Pd; 7) anti-Leishmanial: Au, Ir, Ru, Os, Pd, La; 8) antitrypanosomal: B, Ir, Os, Pd; 9) antiinflammatory: Co, Cu, Mn, Ni, Ru; 10) anti-rheumatic: Au. Schiff bases metal agents possess antimicrobial, antifungal, antiviral, anti-inflammatory, antioxidant, and anticancer activities. N-heterocyclic carbene derivatives are included as ligands in Ag, Au, and Pd complexes with anticancer, and antimicrobial activity. An important trend in the investigation of novel antineoplastic agents is the development of arene complexes, derivatives of Ferrocene, and scorpionates, dinuclear complexes, mixed-ligand strategy. An important perspective trend is the development of natural product-conjugated metal complexes for cancer therapy with ligands from plant origin as Ferrocene podophyllotoxin, Ferrocene¬ conjugates with flavonoids, Ru(II) complexes with 18β-glycyrrhetinic acid, naphthoquinone/p-cymene, Curcumin metal-based complexes.