DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.029

Pages: 708-711

Background: Rickettsial infections are zoonoses caused by Rickettsia species, transmitted mainly by ticks and fleas. While usually mild, they may occasionally lead to severe visceral involvement, including acute kidney injury (AKI). Methods: We report four cases of rickettsial infection complicated by AKI in Morocco, detailing clinical, laboratory, and radiological features, and review the recent literature. Results: All patients presented with fever and generalized rash, with varying gastrointestinal symptoms and multi-organ involvement. Laboratory findings included AKI, thrombocytopenia, elevated inflammatory markers, and hepatic cytolysis. Rickettsial serology was unavailable in all cases. Early treatment with doxycycline and supportive therapy led to rapid clinical and biological recovery. Conclusion: AKI can complicate rickettsial infections. Early clinical recognition and prompt doxycycline therapy are associated with favorable outcomes, even in the absence of confirmatory serology.