DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.051

Pages: 804-806

Background: Penile squamous cell carcinoma (SCC) is a rare malignancy in developed countries. Early diagnosis allows organ-preserving treatment, whereas delayed management may result in disease progression requiring radical surgery. Case Presentation: An 84-year-old circumcised male with diabetes and hypertension presented with a three-year history of a painless verrucous lesion of the glans penis. Initial biopsy demonstrated moderately differentiated invasive SCC. The patient refused surgery and was lost to follow-up. Upon re-presentation, the lesion had progressed to a large ulcerative and exophytic mass involving the entire glans. MRI demonstrated a 21 × 22 × 26 mm lesion with involvement of the corpus spongiosum. Partial penectomy was initially planned; however, positive intraoperative frozen margins required conversion to total penectomy with bilateral inguinal lymph node dissection. Final histopathology revealed intermediate-grade invasive SCC infiltrating the corpus spongiosum (pT2), with negative surgical margins and no nodal metastasis (pN0). Postoperative recovery was uneventful. Conclusion: Delayed management of penile SCC may result in local progression necessitating radical surgery. Early intervention is essential to preserve organ function and improve quality of life.