DOI: https://doi.org/10.36347/sjmcr.2026.v14i05.013

Pages: 920-923

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with heterogeneous presentations, in which acute pancreatitis is a rare but possible initial manifestation. We report the case of a 35-year-old woman with insulin-treated type 2 diabetes mellitus who presented with acute epigastric pain, vomiting, bilateral limb edema, and bullous cutaneous lesions in a context of altered general condition. Laboratory findings showed elevated lipase, nephrotic-range proteinuria, hypocomplementemia, and positive antinuclear and anti-dsDNA antibodies. Imaging confirmed acute pancreatitis, while skin biopsy revealed dermal vasculitis and renal biopsy showed focal segmental hyalinosis. In the absence of common etiologies, the diagnosis of SLE was established. Treatment with high-dose corticosteroids led to rapid clinical improvement. This case highlights the importance of considering SLE in unexplained pancreatitis associated with systemic features to ensure early diagnosis and appropriate management.