DOI: https://doi.org/10.36347/sasjs.2026.v12i05.009

Pages: 381-384

Introduction: Chondroid syringoma is a rare benign cutaneous adnexal tumor of sweat-gland origin, occurring in less than 0.1% of primary skin tumors. It has a predilection for the head and neck, and its clinical appearance is non-specific enough that diagnosis is rarely made before tissue examination. Case Presentation: A 68-year-old woman with no relevant medical history presented with a two-year history of progressive left cheek swelling. Examination revealed a firm, painless, polylobulated nasolabial mass of approximately 2 cm with overlying telangiectasias. CT imaging demonstrated a well-defined 27 × 23 mm soft-tissue lesion containing internal calcifications, abutting the buccinator muscle and facial vessels. Complete excision was performed via an intraoral approach. Histopathology confirmed chondroid syringoma: epithelial ducts, tubules, and nests in a bilayered pattern within a chondromyxoid stroma, with no atypia or infiltrative growth. At one year, the patient remains recurrence-free. Conclusion: Chondroid syringoma should be included in the differential diagnosis of any slow-growing, painless facial mass. Diagnosis requires histopathological confirmation. Complete surgical excision through an approach that minimizes facial scarring provides definitive treatment and an excellent long-term outcome.