DOI: https://doi.org/10.36347/sajb.2026.v14i05.002

Pages: 394-397

This study aimed to evaluate the toxicological potential of the total aqueous extract of Desmodium adscendens leaves (TAEDa) in experimental rats to validate its traditional use in the treatment of liver disorders. Distilled water and TAEDa at doses of 2000, 4000, and 5000 mg/kg bw were administered to four different groups of rats, observed for 14 days to assess acute toxicity. After 14 days, no abnormal behavioral or physical signs were observed. At the end of this same period, the extract at doses of 4000 and 5000 mg/kg bw significantly increased the relative weight of the livers. Conversely, the relative weights of the kidneys, lungs, and heart decreased considerably after administration of the extract at the maximum dose of 5000 mg/kg bw. At the end of the experiment, biochemical analyses showed that transaminase and creatinine levels had increased, whil