DOI: https://doi.org/10.36347/sasjm.2026.v12i05.017

Pages: 454-459

Contrast-enhanced mammography (CEM) is a highly effective functional imaging technique, comparable to MRI, enabling the detection of breast lesions based on their enhancement after contrast injection. We report the case of a patient in whom a contralateral lesion, not confirmed on initial ultrasound-guided biopsy, was re-characterized by contrast-enhanced mammography, revealing a distinct suspicious abnormality. Targeted vacuum-assisted biopsy provided a precise histological diagnosis, allowing appropriate therapeutic management. This case highlights the value of contrast-enhanced mammography-guided biopsy in situations of radiologic–histologic discordance or lesions occult on conventional imaging, offering a reliable and accessible alternative to MRI-guided biopsy.