DOI: https://doi.org/10.36347/sasjm.2026.v12i05.021

Pages: 483-486

Esophageal gastrointestinal stromal tumor (GIST) is an exceptionally rare entity. We report the case of a 60-year-old patient investigated for solid-food dysphagia, in whom the diagnostic workup revealed a large mass involving the lower third of the esophagus with metastatic disease at presentation. The diagnosis was established through histopathological and immunohistochemical examination, demonstrating a mesenchymal proliferation positive for CD117, DOG1, and CD34, consistent with an esophageal GIST. Owing to the advanced stage of the disease, treatment with imatinib was initiated. Through this case, we highlight the rarity of this location, the diagnostic value of immunohistochemistry, and the essential role of targeted therapy in advanced forms.