DOI: https://doi.org/10.36347/sasjs.2026.v12i05.016

Pages: 419-423

Background: Giant cell tumor of the tendon sheath (GCTTS) is a benign proliferative lesion arising from the synovium of tendon sheaths, bursae, or joints. While it commonly affects the hand, involvement of the foot particularly the great toe is exceedingly rare. Case Presentation: We report the case of a 28-year-old patient presenting with a painless, progressively enlarging mass of the right great toe evolving over two years. Clinical examination revealed a firm, bilobed mass measuring 4 cm, adherent to deep planes without inflammatory signs. Radiographs demonstrated a lytic lesion involving the proximal phalanx. Ultrasound showed a hypoechoic, lobulated soft tissue mass. Histopathological examination following biopsy suggested GCTTS. Complete surgical excision was performed, confirming the diagnosis. The postoperative course was uneventful with no recurrence. Discussion: This case highlights the diagnostic challenges of GCTTS in atypical locations such as the foot, where it may mimic other soft tissue tumors. Bone involvement, although not uncommon, can complicate the diagnostic approach and surgical management. Complete excision remains essential to reduce recurrence risk, particularly in anatomically constrained regions. Conclusion: GCTTS of the great toe is rare and may mimic other soft tissue tumors. Surgical excision remains the treatment of choice, but recurrence remains a concern. Early diagnosis and complete resection are essential to improve outcomes.