DOI: https://doi.org/10.36347/sasjs.2026.v12i05.028

Pages: 478-483

Background: Obstructive jaundice is a serious hepatobiliary condition often caused by malignant biliary obstruction, including periampullary tumors. No single imaging modality provides consistently complete diagnostic accuracy, making comparative evaluation necessary. This study compared the diagnostic performance of USG, CT scan, and MRCP in periampullary carcinoma using histopathology as the gold standard. Methods: This retrospective cross-sectional study was conducted in the Department of Surgery at Shaheed Suhrawardy Medical College and Hospital, Dhaka, Bangladesh. A total of 50 histopathologically confirmed periampullary carcinoma patients were included using purposive sampling. After ethical approval and informed consent, data from USG, CT scan, MRCP, and histopathology were collected and analyzed using SPSS version 24, with diagnostic performance parameters calculated (p < 0.05 significant). Results: A total of 50 patients (mean age 48.26 ± 14.88 years; 58% male) were included. Periampullary carcinoma was detected by USG in 72%, CT in 82%, and MRCP in 92%, while histopathology confirmed 96%. MRCP showed the highest accuracy (98%), followed by CT (96%) and USG (92%). MRCP and CT had 100% specificity, whereas USG had highest sensitivity (100%) but lower specificity (87.5%). Overall, MRCP was the most accurate modality, followed by CT and USG. Conclusion: MRCP is the most accurate imaging modality for detecting periampullary carcinoma, followed by CT scan, while USG is useful mainly as an initial screening tool.