DOI: https://doi.org/10.36347/sjams.2026.v14i05.034

Pages: 840-847

Background: Chronic kidney disease (CKD) is a major and increasing global health problem affecting 10–13% of the population, including a rising burden in Bangladesh. Progressive renal dysfunction leads to disturbances in mineral metabolism causing CKD–mineral bone disorder and increased fracture risk. This study aimed to evaluate the biochemical pattern of CKD–mineral bone disorder and its association with fracture risk assessed by the FRAX tool in CKD patients. Methods: This cross sectional study (May 2019–April 2020) was conducted in the Department of Nephrology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh, enrolling 161 CKD patients (≥18 years) to assess mineral bone disorder and fracture risk with FRAX (Indian model, without BMD). Demographic, clinical, and biochemical data were collected, CKD staged per KDIGO, serum analyzed by standard methods, and data processed in SPSS v22.0 (p < 0.05) with ethical approval. Results: Among 161 CKD patients, vitamin D abnormality (95.0%), elevated iPTH (88.2%), phosphate abnormality (68.9%), and calcium abnormality (53.4%) were highly prevalent. Most patients were in CKD stage G5 (47.8%), and diabetes mellitus was the leading cause of CKD (42.2%). No significant association was observed between CKD stage or most biochemical parameters and FRAX-based fracture risk. However, abnormal iPTH levels were significantly associated with increased major osteoporotic and hip fracture risk (p < 0.05). Conclusion: Disordered mineral metabolism was highly prevalent among CKD patients, and abnormal iPTH levels were significantly associated with increased FRAX-based fracture risk.