DOI: https://doi.org/10.36347/sjmcr.2026.v14i05.109

Pages: 1326-1328

Heyde syndrome is a rare condition characterized by severe aortic stenosis and gastrointestinal bleeding from angiodysplasia, associated with an acquired type 2A von Willebrand syndrome. We report three cases: two men and one woman (mean age 70) with severe aortic stenosis (mean valve area 0.6 cm²; mean gradient 65 mmHg) presenting with recurrent gastrointestinal bleeding and iron-deficiency anemia. Endoscopy revealed colonic angiodysplasias in the men, while capsule endoscopy detected jejunal angiodysplasia in the woman. High-molecular-weight von Willebrand factor multimers were reduced in two patients. Despite argon plasma coagulation, bleeding persisted, and all underwent aortic valve replacement, which addressed the underlying hemodynamic abnormality. Heyde syndrome should be suspected in patients with aortic stenosis and unexplained gastrointestinal bleeding. Valve replacement usually resolves bleeding, but persistence may occur, highlighting the need for careful follow-up and a multidisciplinary approach.