DOI: https://doi.org/10.36347/sjmcr.2026.v14i06.009

Pages: 1363-1366

Gynecomastia is a benign proliferation of breast glandular tissue in males, common during adolescence but warranting investigation when persistent or associated with a specific pathological condition. Neurofibromatosis type 1 (NF1) is a multisystemic genetic disorder, whose endocrine manifestations remain rare and poorly described. We report the case of a 17-year-old patient, followed since the age of one year for NF1, presenting with progressive bilateral gynecomastia with normal endocrine, hepatic, and tumor findings. This case illustrates the diagnostic difficulties posed by idiopathic gynecomastia in a specific genetic context and highlights the importance of careful, multidisciplinary management.