DOI: https://doi.org/10.36347/sjmcr.2026.v14i06.026

Pages: 1431-1433

Introduction: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, commonly metastasizing to the liver, lungs, and peritoneum. However, metastasis to the skull, especially the occipital region, is exceedingly rare. This report presents a unique case of skull metastasis originating from advanced distal sigmoid adenocarcinoma, highlighting the importance of considering atypical metastatic sites in CRC patients. Aim: The aim of this report is to discuss the rare occurrence of skull metastasis from CRC, the diagnostic challenges, and the management strategies, emphasizing the need for heightened awareness in clinical practice. Materials and Methods: This case involves a 54-year-old female with a history of distal sigmoid adenocarcinoma, liver and lung metastasis, and a solitary osteolytic lesion in the right occipital skull region. Imaging, including CECT and MRI, was utilized for diagnosis. Treatment involved a multidisciplinary approach with chemotherapy, and palliative care was considered for the management of symptoms. Results and Discussion: The patient presented with a progressively enlarging, painless mass over the right occipital region. Imaging confirmed a metastatic lesion. Despite the rare occurrence of skull metastasis in CRC, this case exemplifies the importance of early detection. Although skull metastasis typically signals systemic spread and poor prognosis, aggressive management, including radiotherapy and chemotherapy, can result in favorable outcomes, particularly in isolated cases. Conclusion: Skull metastasis from CRC is a rare but significant clinical finding. Early identification and a multidisciplinary treatment approach can improve prognosis, especially in atypical metastatic cases. Clinicians should maintain a high index of suspicion for such presentations in patients with a history of CRC.