DOI: https://doi.org/10.36347/sasjs.2026.v12i06.004

Pages: 545-551

Background: Intracranial meningioma is one of the most common primary tumors of the central nervous system. Progesterone receptor (PR) expression has been suggested as a potential marker for predicting tumor behavior. Objective: To evaluate progesterone receptor expression in intracranial meningioma in relation to WHO grade and tumor size. Methods: This cross-sectional observational study was conducted at Bangladesh Medical University (BMU), Dhaka, from June 2018 to March 2020. A total of 35 patients with histopathologically confirmed intracranial meningioma were included. Tumor size and WHO grade were recorded, and PR expression was assessed by immunohistochemistry. Data were analyzed using SPSS version 22. Results: The mean age of the patients was 59.65 ± 16.03 years, with female predominance (57.1%). Most tumors were medium sized (62.9%), and the majority were WHO grade I (88.6%). A significant association was found between PR expression and WHO grade (p = 0.013), with lower PR expression more common in grade II tumors. No significant association was observed between PR expression and tumor size (p = 0.099). Conclusion: Progesterone receptor expression shows a significant association with WHO histological grade in intracranial meningioma, suggesting its potential role as a prognostic indicator of tumor behavior. However, PR expression does not appear to correlate with tumor size.