DOI: https://doi.org/10.36347/sajb.2026.v14i06.005

Pages: 448-454

As part of efforts to develop medicinal plants for the treatment of male infertility, a study was conducted on the effect of an aqueous extract of Carica papaya seeds on endocrine secretions in male Wistar rats. Toxicological analyses performed in accordance with OECD guidelines showed no signs of toxicity in the treated animals. Histopathological studies of the testes and epididymis revealed no structural abnormalities in these organs. Administration of the aqueous extract of Carica papaya seeds led to a significant increase in plasma levels of testosterone and luteinizing hormone (LH) in rats treated at a dose of 1000 mg/kg compared to controls. These results suggest that the aqueous extract of Carica papaya seeds boosted LH and testosterone and thus has a positive effect on male fertility at a dose of 1000 mg/kg body weight.