DOI: https://doi.org/10.36347/sjmcr.2026.v14i06.041

Pages: 1490-1492

DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms syndrome) is a rare but serious drug reaction with the potential for severe multiorgan involvement, particularly hepatic. It is a drug-induced syndrome that can be life-threatening due to the onset of severe visceral manifestations. It is characterized by a long latency period between drug administration and the onset of symptoms, and by a prolonged course often marked by flare-ups even after discontinuation of the causative drug. Its pathophysiology remains incompletely understood and involves reactivation of herpes viruses (HHV-6, HHV-7, EBV, CMV) and a strong immune response directed against these viruses. The drugs may act both on epigenetic control to promote viral reactivation and on an antiviral T-lymphocyte (T-lymphocyte) immune response by interacting with the major histocompatibility complex receptor in genetically predisposed individuals.