DOI: https://doi.org/10.36347/sjmcr.2026.v14i06.043

Pages: 1495-1499

Primary anorectal melanoma is a rare malignant tumor, accounting for less than 1% of anorectal cancers and 1–3% of all melanomas. It is characterized by marked aggressiveness and a high potential for early metastasis. Diagnosis is often delayed due to nonspecific clinical manifestations. We report two case reports illustrating the diversity of clinical presentations and treatment modalities. The first case involves a 52-year-old male patient with a locally advanced form of the disease who had an unfavorable course during immunotherapy. The second case involves a 73-yearold female patient treated with chemoradiotherapy due to a surgical contraindication. Diagnosis relies on histopathological examination supplemented by immunohistochemistry. Standard treatment protocols remain undefined. The prognosis remains poor, with very limited overall survival.