DOI: https://doi.org/10.36347/sjmcr.2026.v14i06.048

Pages: 1512-1515

Primary biliary cholangitis (PBC) is a rare cause of cholestatic jaundice in men. We report two rare cases of PBC in men presenting with chronic cholestasis (jaundice, pruritus, dark urine, pale stools, alkaline phosphatase (ALP) greater than 1.5 times the upper limit of normal, and glucocorticoids (GGT) greater than 3 times the upper limit of normal). The first case had positive anti-mitochondrial type 2 antibodies, while in the second, these antibodies were negative, with positive anti-gp210 antibodies. Histological confirmation of PBC in the first case was achieved. The second case was diagnosed at the stage of cirrhosis, based on signs of portal hypertension and liver parenchymal dysmorphism on imaging. Both patients were treated with ursodeoxycholic acid.