DOI: https://doi.org/10.36347/sasjm.2026.v12i06.015

Pages: 656-659

Background: Burkitt lymphoma (BL) is an aggressive AIDS-defining B-cell non-Hodgkin lymphoma. Its simultaneous occurrence with severe opportunistic infections at HIV diagnosis represents an exceptional and life-threatening scenario. Case Presentation: A 36-year-old male with newly diagnosed HIV infection (viral load >10,000,000 copies/mL) presented simultaneously with invasive pulmonary aspergillosis, oropharyngeal-esophageal candidiasis, marked hepatic impairment, and a multinodular hepatic pattern with a suspicious pancreatic lesion on MRI. Inguinal lymph node biopsy confirmed Burkitt lymphoma with a starry-sky histological pattern. Liposomal amphotericin B was initiated first, followed by TDF/3TC/DTG antiretroviral therapy. After emergency transfer to hematology, the patient died approximately three weeks after chemotherapy initiation. Conclusion: This case highlights the exceptional prognostic severity of BL diagnosed concurrently with AIDS-defining opportunistic infections, and underscores the need for early HIV diagnosis, systematic lymph node biopsy in immunocompromised patients, and multidisciplinary management.