DOI: https://doi.org/10.36347/sjmcr.2026.v14i06.054

Pages: 1551-1555

Plummer-Vinson syndrome (PVS) is a rare disorder characterized by dysphagia, iron-deficiency anemia, and esophageal webs. Although it is classically associated with upper aerodigestive tract malignancies, its coexistence with gastric cancer is exceptionally rare. We report the case of a 66-year-old man with chronic iron-deficiency anemia who presented with progressive dysphagia, severe asthenia, weight loss, and malnutrition. Laboratory investigations revealed profound microcytic hypochromic anemia with markedly reduced ferritin levels. Upper gastrointestinal endoscopy demonstrated an impassable cervical esophageal web, confirming the diagnosis of PVS. Following endoscopic balloon dilation, further evaluation revealed thickened ulcerated gastric folds in the fundus. Histopathological examination of gastric biopsies showed a moderately differentiated gastric adenocarcinoma without evidence of metastatic disease. After nutritional optimization, the patient underwent total gastrectomy and perioperative chemotherapy, with a favorable outcome at three months of follow-up. This case highlights a very rare association between PVS and gastric adenocarcinoma and underscores the importance of comprehensive gastrointestinal evaluation in patients with persistent iron-deficiency anemia and constitutional symptoms. Early recognition may facilitate timely diagnosis and management of underlying malignancies, potentially improving patient outcomes.