DOI: https://doi.org/10.36347/sjmcr.2026.v14i07.001

Pages: 1615-1619

Sinonasal chondrosarcoma is a rare malignant cartilaginous neoplasm accounting for a small proportion of head and neck sarcomas. Owing to its indolent growth and nonspecific clinical presentation, diagnosis is frequently delayed. Complete surgical excision remains the cornerstone of treatment; however, radical resection may be challenging in locally advanced tumors involving critical anatomical structures. We report the case of a 54-year-old woman presenting with progressive bilateral nasal obstruction, facial pain, and epiphora. Imaging revealed a locally advanced destructive tumor centered on the nasal septum with extension to the sphenoid sinus, hard palate, and nasopharynx. Endoscopic decompressive surgery was performed, and histopathological examination confirmed a grade 2 chondrosarcoma. Following multidisciplinary discussion, the patient underwent definitive radiotherapy using volumetric modulated arc therapy (VMAT) to a total dose of 70 Gy delivered in 35 fractions. Treatment was well tolerated, with only grade 1 mucositis. Post-treatment magnetic resonance imaging demonstrated radiological stability of the residual tumor, accompanied by significant clinical improvement. One year after completion of radiotherapy, the patient remained clinically stable with sustained symptomatic improvement and no evidence of clinical disease progression. This case highlights the potential role of definitive high-dose radiotherapy in achieving durable disease stabilization and clinical control of locally advanced sinonasal chondrosarcoma following non-radical surgery.