DOI: https://doi.org/10.36347/sjmcr.2026.v14i09.024

Pages: 2058-2062

Necrotizing sialometaplasia (NS) is an uncommon, self-limiting, benign inflammatory condition, which involves predominantly the minor salivary glands. Its prevalence is 0.03% of oral mucosa lesions biopsied. It is known to be related to local factors that may cause vascular obstruction, with consequent infarction and ischemic necrosis of the salivary glands nevertheless it can be the manifestation of a specific systemic condition. The aim of this case report is to describe the clinical and histopathological aspect of this lesion and to determine the potential association with gastric disorders (GD). We present a case of 45-year-old male patient with bilateral ulcerative lesion on the hard palate who suffered from gastric ulcer and gastroesophageal reflux disease (GORD). A biopsy was performed, and a histopathological diagnosis of NS was established. The possible contribution of gastrointestinal disorders to the pathogenesis of NS is discussed. Given the diagnostic difficulty and risk for aggressive management strategies, necrotizing sialometaplasia is an important diagnostic entity to consider in patients with oral ulcerative lesions. Reassurance and observation are the primary management strategy, as these lesions spontaneously resolve over time.