DOI: https://doi.org/10.36347/sasjm.2026.v12i09.025

Pages: 959-965

Background: Intermediate syndrome (IMS) is an important neurological complication of acute organophosphorus (OP) poisoning and may cause significant respiratory and neuromuscular morbidity. This study assessed the clinical profile, treatment outcomes, and mortality among patients who developed IMS following acute OP poisoning. Objective: To assess the clinical profile, treatment outcomes, and mortality among patients with intermediate syndrome following acute organophosphorus poisoning. Methods: This observational study was conducted in the Department of Medicine, Jahurul Islam Medical College & Hospital, Bajitpur, Bangladesh, over six months from May 2016 to October 2016. Fifty consecutive patients aged >12 years who developed IMS following acute OP poisoning were enrolled. Clinical manifestations, complications, respiratory support, and final outcomes were recorded. Data were analyzed using SPSS version 20.0. Quantitative variables were expressed as mean±SD and qualitative variables as frequency and percentage. A p-value <0.05 was considered statistically significant. Results: The mean age was 26.33±5.14 years (range 16–69 years), and 38.0% were aged 21–30 years. Females comprised 62.0% of participants. Respiratory muscle weakness was the most common manifestation (44.0%), followed by neck muscle weakness (30.0%) and proximal muscle weakness (28.0%). Cranial nerve palsy occurred in 16.0%. Respiratory failure occurred in 8.0%, multiorgan failure in 22.0%, and 30.0% required mechanical ventilatory support. Overall, 76.0% survived and 24.0% died. Mortality was significantly higher among males than females (52.6% vs. 6.5%; p<0.001). Conclusion: IMS following acute OP poisoning was associated with substantial respiratory complications and mortality. Early recognition and close respiratory monitoring are essential for timely supportive and ventilatory management.