DOI: https://doi.org/10.36347/sjds.2026.v13i09.002

Pages: 177-182

Introduction: Periodontal diseases are prevalent chronic inflammatory disorders affecting the tooth-supporting apparatus and remain a substantial clinical burden despite established therapeutic approaches. Mesotherapy, defined as the localized microinjection of pharmacologic or bioactive agents into target tissues, has emerged as a minimally invasive adjunctive strategy with potential relevance in periodontal care. Methods: A narrative review was conducted through electronic searches of major databases for English-language publications available up to December 2025. Search terms included mesotherapy, periodontitis, gingivitis, periodontal regeneration, local drug delivery, intra-gingival injection, and gingival depigmentation. Eligible literature comprised preclinical studies, clinical trials, case reports, case series, and relevant review articles addressing periodontal inflammation, regenerative outcomes, or gingival esthetics. Owing to marked heterogeneity in study design, interventions, and outcome measures, findings were synthesized narratively. Results: The available evidence suggests that mesotherapy may confer localized anti-inflammatory, wound-healing, regenerative, and esthetic benefits in selected periodontal applications. Reported agents include vitamin C, hyaluronic acid, growth factors, platelet-rich plasma, glutathione, tranexamic acid, and antioxidant formulations. Early studies indicate possible reductions in gingival inflammation, improved tissue healing, enhanced patient comfort, and favorable outcomes in gingival depigmentation. Proposed mechanisms include targeted local delivery, modulation of inflammatory pathways, and stimulation of reparative cellular responses. Discussion: Mesotherapy is biologically plausible and clinically promising, but the current evidence remains preliminary and methodologically heterogeneous. Standardized protocols, adequately powered randomized controlled trials, and long-term follow-up are required before mesotherapy