DOI: https://doi.org/10.36347/sjmcr.2026.v14i10.056

Pages: 2373-2375

Introduction: Primary cerebral lymphoma is a rare condition that mainly affects elderly and immunocompromised individuals. Its occurrence in immunocompetent patients is unusual, representing 1% of non-Hodgkin lymphomas and 5% of all brain tumors. The goal of our study is to report 3 cases of primary lymphoma in immunocompetent patients and to discuss the epidemiological and clinico-anatomical features, as well as the treatment options and prognosis of this tumor through the literature. Observations: The first patient was a 52-year-old admitted for aphasia and headaches; the MRI showed a deep portal lesion invading the corpus callosum. The second patient, 75 years old, had hemiplegia without signs of increased intracranial pressure, with a brain CT showing a parietal lesion. As for the last patient, he consulted for headaches with a decline in general condition, and imaging revealed a large tumor process in the right fronto-temporo-parietal cranial vault. All three, after a biopsy-excision, whose histology described large B-cell non-Hodgkin malignant lymphomas, all received induction chemotherapy and intrathecal methotrexate injections followed by a whole-brain radiotherapy of 40Gy with a good response. Conclusion: LCP, once mainly seen in immunocompromised patients, is now increasingly common in older, immunocompetent individuals, often with deep-seated involvement. Its management is multidisciplinary, involving surgery mainly for diagnostic confirmation, chemotherapy, and radiotherapy. Despite this, the prognosis remains poor, with high recurrence rates and limited overall survival, especially in elderly or frail patients.