DOI: 10.36347/sajb.2020.v08i07.004

Pages: 214-220

NFE2 related factor 2 (NRF2) is a major mechanism in the cellular defense against oxidative or electrophilic stress. The activation of the Nrf2 is needed in the production of antioxidant elements such as Glutathione. So any defect in the NRF2 gene may affect the production of antioxidant molecules. The aim of the current setting is the detection of a deletion mutation in exon 2 of the NRF2 and its association with the level of glutathione in Breast cancer with late stages. The current study was conducted on Sudanese females with Breast Cancer who attended the Institute of Nuclear Medicine – Madani – SUDAN between August to October / 2018. The procedure was included in the serological part to measure Glutathione in plasma and molecular part to detect deletion mutation in the NRF2 gene (exon 2). We found a higher level of glutathione in patients compared with the control p-value < 0.0001. In addition to that, we obtained a positive correlation between a high level of glutathione and different breast cancer stages (r = 0.882), also a deletion mutation in NRF2 exon 2 in 15% of patients and 3% in control was found. Our findings suggest that it could be there is a relationship between increased level of glutathione and progressive late stages in patients but this increased it may not attribute only to exon 2 deletion mutation of the NRF2, maybe there are unknown factors are participate in this increasing.