DOI: 10.36347/sajb.2020.v08i09.004

Pages: 284-291

Ganoderma lucidum (Gl), collected from Saki, Oyo State, South Western Nigeria, was employed as dietary supplements in the assessments of blood-boosting and gastro-protective actions on male Wistar rats (Rattus norvegicus). The antiulcer, biochemical and haematological influences were carried out in triplicates using standard methods. Data were expressed as Mean ± SE, interpreted using ANOVA and test of significance was carried out using DMRT (P≤ 0.05). Gastric nitric oxide, mucin, sulfhydryl, hydrogen peroxide and H+/K+-ATPase activities were significantly different when compared with ulcerated untreated control (CU). When the same parameters were used in comparison with the normal control (CN), values obtained for haematological and plasma biochemical variables were not significantly different across all G. lucidum treatment groups. The histopathological analysis of the stomach tissues revealed that there were marked ulcer inhibitions. G. lucidum treatment group demonstrated blood enhancing and gastro-protective behavior through predominant antioxidant activities. The implications of these findings were discussed.