DOI: 10.36347/sajb.2020.v08i09.005

Pages: 292-300

Antiulcer and blood-boosting activities of feeds supplemented with Trametes versicolar (Tv) in Wistar rats (Rattus norvegicus) were studied. Haematological studies and antiulcer biochemical analysis were carried out on the rats using standard methods. Data were presented as Mean ± SEM, analyzed using two-way ANOVA and p ≤ 0.05 was significantly different in all the variables. Haematological parameters were not significantly different across all Tv treatments when compared with the control (CN). There were also significant differences in values obtained for gastric ulcer inhibition, nitric oxide, mucin, sulfhydryl, and H+/K+-ATPase. Tv treatment groups also differed when compared with ulcerated untreated control (CU). The pathological changes detected from histological studies on the stomach tissues showed inhibition of ulcers. Tv treatment groups demonstrated blood boosting and antiulcer activity through synergistic activities of mucin, H+/K+ ATPase activity, and antioxidant mechanism. The implications of these observations are discussed.